:orphan: true

.. _rosetta-DARC-docking:

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Rosetta DARC Docking
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This protocol follows the `DARC <https://pubmed.ncbi.nlm.nih.gov/26181386/>`_ docking procedure.
It can take as input either an ``AtomStruct`` (where you would need to define the residue(s) where the docking will be 
performed around) or a ``SetOfStructROIs`` (to directly define the region as a Structural Regions Of Interest).

By default, DARC works only matching the shape of the ligand and receptor, but the user can input a electrostatic 
grid built by AutoDock to take into account also electrostatics, which might substantially increase the performance.

Input
----------------------------------------
.. include:: ../../../templates/plugins/input-help.rst

.. image:: ../../../../_static/images/plugins/rosetta/DARC-docking/form.png
   :alt: Rosetta DARC Docking form
   :height: 400
   :align: center

|

The results of these protocols are a ``SetOfSmallMolecules``, containing the predicted binding poses for the input
molecules. The user can visualize them using **Analyze Results**, which will display the General SmallMolecules viewer.
Using this viewer you can also visualize the rays that define the "pockets" where the molecules are docked.

.. |testCommand| replace:: rosetta.tests.test_darc.TestDARC
.. include:: ../../../templates/plugins/protocol-test.rst